pentobarbital decreases amounts of toremifene by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers raise amount of toremifene metabolism, reducing the constant-condition concentration in serum.
pentobarbital will lessen the level or outcome of ripretinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
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pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Caution/Check. Drugs that increase delta-aminolevulinic acid synthetase might decrease hemin influence.
This drug may well interfere Using the absorption of orally administered griseofulvin, reducing its blood concentrations; effects of blood degree reduction mysterious; preferable to avoid concomitant administration of those drugs
pentobarbital will lower the level or outcome of pantoprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.
pentobarbital will lessen the level or influence of midazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital and daridorexant both raise sedation. Modify Therapy/Keep an eye on Closely. Coadministration here boosts threat of CNS despair, which may result in additive impairment of psychomotor efficiency and cause daytime impairment.
pentobarbital will lower the extent or outcome of etoposide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will decrease the extent or impact of eltrombopag by influencing hepatic enzyme CYP2C9/ten metabolism. Use Caution/Watch.
pentobarbital will lower the extent or effect of estradiol vaginal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will lower the extent or effect of apremilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration with strong CYP inducers leads to a big decrease of systemic exposure of apremilast, which may end in lack of efficacy
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pentobarbital will lessen the level or impact of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is often a sensitive CYP3A4 substrate. Coadministration with powerful or average CYP3A4 inducers is contraindicated.